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Africa: CEPI Partners With Avaref to Boost Clinical Trial Application Reviews in Africa

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Brazzaville/Oslo — New funding to the AdVAncIng Clinical TRials Excellence in Africa (AVAREF) could help accelerate the development of life-saving vaccines to contain infectious disease outbreaks on the continent.
The Coalition for Epidemic Preparedness Innovations (CEPI) is providing $1 million to AVAREF as part of a new two-year project to enhance the efficiency with which African regulatory agencies and ethics committees–who are already part of the AVAREF network–review and make emergency decisions on multi-country clinical trial applications. Part of the funding will also support AVAREF to coordinate and further fine-tune the procedure for issuing scientific advice to developers, an important element which aids the development and eventual licensure of vaccines and other health products.
At present, not all countries on the continent have emergency review and scientific advice procedures suitable for public health emergencies. In certain cases, the standard time to review a clinical trial application, often driven by sequential ethics and regulatory reviews, could take anywhere between 6-18 months – by which point an outbreak could have spread beyond containment.
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With CEPI funding, experts at national regulatory authorities and ethics committees across Africa will gain further experience in accelerating the regulatory process by participating in existing AVAREF scientific advice, joint emergency reviews and simulation exercises. The emergency joint review process is used by AVAREF to bring together relevant national authorities of regulators and ethics committees and decide whether a clinical trial–typically submitted to AVAREF by a vaccine developer looking to run a multi-country study–is to be approved and enable recruitment of participants in as little as 10 to 15 days from receiving the application, without compromising robust technical considerations.
Greater understanding and experience in issuing scientific advice and in approving clinical trial submissions could help AVAREF safely accelerate the parallel regulatory and ethics review of the clinical trial applications of vaccine and other health intervention candidates during a future epidemic or pandemic threat affecting Africa. Expedited mechanisms could support faster regulatory approvals, meeting CEPI’s ambitious goal to develop a new vaccine in response to a novel outbreak in as little as 100 days.
Jacqueline Rodgers, Senior Regulatory Affairs Lead for Africa at CEPI, said: “From Mpox to Marburg and Ebola Sudan to Lassa fever, Africa has tackled an abundance of deadly outbreaks in recent years and vaccines are urgently needed to mitigate these persistent threats. Each day counts in an outbreak, so rapid meaningful response to requests for scientific advice and well-designed vaccine clinical trials that meet the criteria for emergency approval by relevant authorities can be a game changer in helping to control the spread of a disease. Building robust, pandemic-ready regulatory systems on the continent advances Africa’s self-sufficiency, with more streamlined and efficient AVAREF processes acting as models that could drive the establishment of similar AVAREF-like forums in Asia and the Americas to fulfill a vision of global preparedness.”
Emphasizing the importance of this collaboration, Dr Benido Impouma, Director of Health Promotion / Diseases and Prevention Control Cluster at the World Health Organization, Regional Office for Africa, said: “We greatly appreciate CEPI’s financial support to AVAREF. This contribution will strengthen the capacity of African regulatory authorities and ethics committees to conduct timely and high-quality reviews of clinical trial applications. With WHO’s continued support, this partnership will help countries accelerate access to safe and effective vaccines and health products, protect communities, and improve preparedness for future health emergencies. Together, we are building stronger systems that safeguard the health and security of our communities.”
AVAREF supports the countries by identifying subject matter experts from within the continent, as well as globally to support the scientific advice process. CEPI funding allows for simulations of this process, in preparation for product development to address epidemics and future pandemics including an unknown ‘Disease X’. Experiencing the joint review process and simulation exercises can provide national regulators and relevant ethics committees with insights on how to better optimise local clinical trial application review timelines and share knowledge with peers also involved in the process.
Regulatory experts from Germany’s medical regulatory body, the Paul Ehrlich Institute, will provide expertise to support simulations and training elements of the project.
About CEPI
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CEPI is an innovative partnership between public, private, philanthropic, and civil organisations. Its mission is to accelerate the development of vaccines and other biologic countermeasures against epidemic and pandemic threats so they can be accessible to all people in need. CEPI has supported the development of more than 60 vaccine candidates or platform technologies against multiple known high-risk pathogens or a future Disease X. Central to CEPI’s pandemic-beating plan is the ‘100 Days Mission’ to compress the time taken to develop safe, effective, globally accessible vaccines against new threats to just 100 days. Learn more at CEPI.net.
About AVAREF
The AdVAncIng Clinical TRials Excellence in Africa (AVAREF), created by WHO in 2006, is a regional platform that brings together all 55 African national regulatory authorities and ethics committees. By strengthening collaboration and building expertise, AVAREF helps countries harmonize and accelerate clinical trial reviews. Its mission is to ensure that safe, effective, and quality-assured vaccines and medical products reach African populations more quickly, especially during public health emergencies. Learn more at AVAREF.
Read the original article on WHO-AFRO.
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Africa: Gambia Slip to Guinea Bissau in Wafu a U-17 Cup of Nations Starter

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The Gambia on Sunday lost to Guinea Bissau 2-0 in their opening match of the 2025 WAFU A U-17 Cup of Nations played at the Stade Mamadou Konateh.
The Baby Scorpions made an astonishing start to the match and contained Guinea Bissau in the midfield, crafting several goal scoring opportunities.
Bisenty Mendy could have opened the scores for The Gambia twice in the first half but his shots went away.
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Alieu Drammeh also came very close to opening the scores for the Baby Scorpions during the first half but his shot went over the cross bar.
Guinea Bissau opened the scores before half time.
The Gambia reacted quickly for an equaliser and created goal scoring opportunities but were wasteful in front of goal thus the first half ended 1-0 in favour of Guinea Bissau.
Upon resumption of the match, The Gambia injected in several fresh legs to fancy their chances of levelling the scores.
The Baby Scorpions mounted heavy pressure on Guinea Bissau and created many goal scoring opportunities but failed to capitalise on them.
Guinea Bissau scored their second goal in the dying minute of the match to dart The Gambia’s hopes of coming back to their feet.
The Gambia fought hard for an equaliser and piled heavy pressure on Guinea Bissau, creating goal scoring chances but failed to materialise on them thus the match ended 2-0 in favour of Guinea Bissau.
The win earns Guinea Bissau second-place in Group A of the 2025 WAFU A U-17 Cup of Nations with 3 points in one group match.
The Baby Scorpions occupy third-place in Group A of the sub-regional cadet biggest football fiesta without a point after one group match.
The Gambia need to beat Liberia in their second group match on Wednesday to increase their chances of cruising to the semi-finals of the 2025 WAFU A U-17 Cup of Nations.
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Read the original article on The Point.
AllAfrica publishes around 600 reports a day from more than 110 news organizations and over 500 other institutions and individuals, representing a diversity of positions on every topic. We publish news and views ranging from vigorous opponents of governments to government publications and spokespersons. Publishers named above each report are responsible for their own content, which AllAfrica does not have the legal right to edit or correct.
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AllAfrica is a voice of, by and about Africa – aggregating, producing and distributing 600 news and information items daily from over 110 African news organizations and our own reporters to an African and global public. We operate from Cape Town, Dakar, Abuja, Johannesburg, Nairobi and Washington DC.
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Africa: AUC Chairperson Received H.E. Ruslan Nasibov, Ambassador of the Republic of Azerbaijan

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Last week, the Chairperson of the African Union Commission, H.E. Mahmoud Ali Youssouf, received H.E. Ruslan Nasibov, Ambassador of the Republic of Azerbaijan to Ethiopia & Permanent Representative to the AU.
They exchanged on strengthening Africa-Azerbaijan relations. The Chairperson commended Azerbaijan’s constructive diplomacy and efforts toward peace, including in its region.
Ambassador Nasibov congratulated the Chairperson on his election and conveyed his country’s continued support, as well as a personal invitation from President Ilham Aliyev to visit Azerbaijan and participate in the World Urban Forum in Baku next year.
Read the original article on African Union.
AllAfrica publishes around 600 reports a day from more than 110 news organizations and over 500 other institutions and individuals, representing a diversity of positions on every topic. We publish news and views ranging from vigorous opponents of governments to government publications and spokespersons. Publishers named above each report are responsible for their own content, which AllAfrica does not have the legal right to edit or correct.
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Africa: Women's Leadership Role in Peace and Security Issues 'Going in Reverse', UN Chief Warns

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More women must have a role in shaping peace agreements, security reforms and post-conflict recovery plans, UN Secretary-General António Guterres told the Security Council on Monday.
Members met for their annual open debate on the women, peace and security agenda just ahead of the 25th anniversary of the Council’s landmark resolution 1325 (2000) on the issue.
As the Secretary-General noted, the resolution “gave voice to a simple truth: women’s leadership is central to just and lasting peace“, in addition to inspiring countless other resolutions, reports and roundtables.
World falling short
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“But let’s speak frankly,” he said. “Too often, we gather in rooms like this one – full of conviction and commitment – only to fall short when it comes to real change in the lives of women and girls caught in conflict.”
In a recent report, Mr. Guterres highlighted progress made over the past quarter century, which includes more than 100 countries adopting national action plans on women, peace and security.
“But gains are fragile and – very worryingly – going in reverse,” he warned.
“Around the globe, we see troubling trends in military spending, more armed conflicts, and more shocking brutality against women and girls.”
Conflict, sexual violence and harassment
Last year, some 676 million women worldwide lived within 50 kilometres of deadly conflict events – the highest number in decades, he said.
Sexual violence also surged, with a 35 per cent rise in incidents against girls. In some places, they accounted for nearly half of all victims.
Mr. Guterres highlighted how women in public life such as politicians, journalists and human rights defenders, are being targeted with violence and harassment, before turning to the situation in Afghanistan where “the systematic erasure of women and girls from public life is in overdrive”.
Additionally, women and girls in the Occupied Palestinian Territory, Sudan, Haiti, Myanmar and beyond, face grave risks and horrific levels of violence.
“And while women’s organizations remain lifelines for millions in crisis, they are being starved of resources,” he added, citing a recent survey by UN Women, which champions gender equality globally.
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It revealed that 90 per cent of local women-led groups in conflict settings are in dire financial straits, with nearly half expected to shut down within six months.
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The Secretary-General urged UN Member States to accelerate commitments on women, peace and security, in line with the Pact for the Future adopted last year. He outlined areas for action, including ramping up funding for women’s organizations in conflict-affected countries.
He also stressed the need for greater participation by women who “must be at the table – not as tokens, but as equal partners“, as well as accountability for perpetrators of gender-based violence, including conflict-related sexual violence.
Refocus, recommit and deliver
Sima Bahous, Executive Director of UN Women, was adamant that the 25th anniversary of resolution 1325 “must be more than a commemoration.”
“Women and girls who live amidst conflict deserve more than commemoration,” she said. “It must instead be a moment to refocus, recommit, and ensure that the next 25 years deliver much more than the last.”
he noted that the meeting was taking place against the backdrop of the war in Gaza, where “a glimmer of hope emerges”, and she welcomed the positive responses to US President Donald Trump’s plan to end the fighting.
Looking ahead to the next 25 years for the women, peace and security agenda, Ms. Bahous told the Council it was crucial to have more funding earmarked, robust quotas and more accountability “that make failures visible”.
More to follow…
Read the original article on UN News.
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AllAfrica is a voice of, by and about Africa – aggregating, producing and distributing 600 news and information items daily from over 110 African news organizations and our own reporters to an African and global public. We operate from Cape Town, Dakar, Abuja, Johannesburg, Nairobi and Washington DC.
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