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Africa: New Dosing Guidance for Dolutegravir Allows Neonates Born to Mothers with HIV to Access this ARV Drug for the First Time – CROI Research

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San Francisco — The PETITE-DTG study evaluated dolutegravir (DTG)  a drug that revolutionized HIV treatment in adults and children  in infants less than 28 days old, using a pediatric 5 mg dispersible tablet (DTG-DT) and a novel 5 mg oral dispersible Film (DTG-Film).
New research has determined the appropriate dosing of a key treatment for neonates (aged <28 days) born to women living with HIV. The study, presented at the 2025 Conference on Retroviruses and Opportunistic Infections (CROI), is a significant advancement in HIV treatment (please see the study abstract below).
Neonates require potent antiretroviral drugs (ARVs) against HIV but there are fewer drugs available for children compared to adults. Administering the correct neonatal dose of ARVs can be challenging due to rapid body weight changes and physiological developments in early life. Therefore, it remains a priority to generate dosing and safety information for the newest ARVs in neonates.
Dolutegravir is recommended by the World Health Organization (WHO) for children and adults living with HIV. Since its approval in 2013, DTG has emerged as a more effective and cost-efficient alternative to older ARV regimens. Currently, DTG is used to treat more than 22 million people in 110 low- and middle-income countries but no DTG dosing guidance had been available for neonates.
Recognizing this critical gap, the World Health Organization (WHO) Paediatric Antiretroviral Drug Optimization (PADO) group prioritized neonatal DTG dosing as an urgent research need to be addressed. In response, the PETITE-DTG study — funded by Unitaid under the BENEFIT-KIDS project — was launched to assess the safety and pharmacokinetics (PK) of DTG in neonates (≥2 kg birth weight) born to mothers on DTG-based treatment.
The PETITE-DTG study was conducted through the newly established PETITE PLATFORM. This platform is a research collaboration between Dr. Adrie Bekker at Stellenbosch University in South Africa and Dr. Tim. R. Cressey at Chiang Mai University in Thailand, and is dedicated to expediting use of latest pediatric ARVs to neonates through safety and PK studies.
Dr. Cressey said, “The PETITE PLATFORM is helping to accelerate the development of neonatal dosing recommendations for ARV drugs. Our goal is to ensure that newborn babies can also benefit from the latest advancements in HIV care”.
The PETITE-DTG study assessed two pediatric DTG formulations, a 5 mg dispersible tablet (DTG-DT) and a novel 5 mg oral dispersible film (DTG-Film). Forty-one term neonates were enrolled at Tygerberg Hospital and administered DTG-DT or DTG-Film for HIV prevention. The dosing regimen consisted of 5 mg DTG every 48 hours from birth to Day 14 of life, followed by 5 mg every day until four weeks of age. The results demonstrated that this DTG dosing strategy was safe, acceptable and maintained efficacious drug levels.
Dr. Bekker said, “It is exciting that these data will support for the first time the use of dolutegravir in neonates. This dosing strategy can now be rapidly implemented across different settings due to the widespread availability of pediatric DTG.”
Both DTG formulations were successfully administered, with solid formulations preferred over syrups. Of note, this was the first evaluation of an ARV oral film in neonates, administered by placing the film directly on the tongue. Despite being a new experience, mothers found this method highly acceptable.
Dr. Lario Viljoen of Stellenbosch University said, “It has been encouraging to see how mothers engage with these novel formulations; we observed high levels of acceptability across the trial. With appropriate messaging and support, these findings can be used to inform future care for infants.”
One mother who participated in the trial along with her infant son said, “As soon as I put [the DTG-Film] on his tongue … it just dissolves in a few seconds, he enjoys it.”
A second mother noted, “[DTG-DT] has been manageable… it dissolves quickly, and then I give it to [my baby]… she does like it, it smells nice”
The pediatric DTG formulations were kindly donated to the PETITE-DTG study by Viatris Ltd. (DTG-DT) and Laurus Labs Ltd. (DTG-Film).
Adapting current and novel pediatric ARVs — as done in the PETITE-DTG study — strengthens efforts to improve HIV prevention and treatment options for neonates, potentially leading to better outcomes. According to UNAIDS, new HIV infections among children declined by 62% between 2010 and 2023, partly reflecting the impact of enhanced treatment strategies.
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Additional PETITE research presented at CROI 2025 explored the alignment of abacavir/lamivudine (ABC/3TC) dosing with DTG in neonates, which paves the way for harmonized neonatal ARV dosing strategies.
The four abstracts presented at CROI 2025 include:

Abstract # Title
#122 Multi-Dose PK/Safety of Dolutegravir Dispersible Tablets & Oral Films in Neonates: PETITE-DTG Study
#1044 Maternal Antiretroviral Formulation Preferences for Neonates
#1045 Acceptability of a Dolutegravir Dispersible Tablet and a Novel Oral Film Formulation in Neonates
#1048 Alternative Dosing of ABC/3TC Dispersible Tablets to Align with Dolutegravir Dosing in Neonates

Overall, these findings provide essential evidence to support DTG extension to neonates, closing a key knowledge gap.
“The easier we can make it for a child to take their medicines regularly, the more likely it is that they will complete their treatment successfully,” says Cherise Scott, Senior Technical Manager at Unitaid. “We will not allow children to be neglected in global health responses simply because their needs are more complex.”
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AllAfrica publishes around 500 reports a day from more than 110 news organizations and over 500 other institutions and individuals, representing a diversity of positions on every topic. We publish news and views ranging from vigorous opponents of governments to government publications and spokespersons. Publishers named above each report are responsible for their own content, which AllAfrica does not have the legal right to edit or correct.
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Africa: 'Paris Noir' Exhibition Showcases Work Made in French Capital By Black Artists

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The ‘Paris Noir’ exhibition at the Pompidou Centre brings together works by African, American, Caribbean and Afro-descendant artists who lived and worked in Paris between the 1950s and the end of the 1990s.
Wifredo Lam, Beauford Delaney, Ernest Breleur, Skunder Boghossian, Christian Lattier, Demas Nwoko, Edward Glissant, Frantz Fanon, Aimé Césaire, Grace Jones… These are just some of the artists whose paintings, film and audiovisual works have gone on display at the Pompidou Centre.
And then there are the American creators famed for their work produced in Paris, including Faith Ringgold, Josephine Baker and author James Balwin. Countries from Cuba, Haiti and Jamaica to Martinique, Côte d’Ivoire and Senegal are also among those represented.
An exhibition like ‘Paris Noir‘ has been long awaited at Paris’s flagship modern art museum, despite a strong black, African and Caribbean presence in the French capital, for centuries.
It includes displays on the creation of the seminal magazine Présence Africaine (now also a publishing house) and that of Revue noire, which chronicled the presence and influence of black artists in France between the 1950s and 2000s.
The Pompidou Centre has also included new works by contemporary artists from Transatlantic African American and European communities, such as Jon One, Valérie John, Nathalie Leroy Fiévee, Jay Ramier and Shuck One.
Black consciousness
Eva Barois De Caevel is one of the exhibition curators. “This in-depth work, a historiographical challenge, is now presenting more than 300 works and even more objects and artefacts,” she told RFI.
The event is the result of two years of work by the Pompidou Centre’s contemporary and prospective creation department, led by Alicia Knock.
Contemporary African culture centre to open in Paris after four-year delay
Knock was particularly insistent on including the works of artists who came to Paris in the 1950s, during the period of anti-colonial struggle which was “organised through alliances between the Americas and Africa”, thanks to methods of resistance born in the Caribbean since the Haitian revolution.
“We could have called the show ‘Paris, Dakar’, ‘Paris, Lagos’, ‘Paris, Johannesburg’, ‘Paris, Havana’, ‘Paris, Fort-de-France’, or ‘Paris, Port-au-Prince’… But this would have been a bias that didn’t interest us,” De Caevel added.
Instead, the museum sought to focus on the idea of a black consciousness, referencing The Black Atlantic, the seminal book by British sociologist and cultural studies academic Paul Gilroy, published in 1993, an exploration of the “double consciousness” of black people in the western world during the modern period.
The curators have included artistic representations of the experience of enslavement and the slave trade, which De Caevel called “unprecedented in the history of humanity, which gives us a common base”.
Equally vital to include was the experience of racism, including institutional racism. “This means that these artists were ignored,” added De Caevel, “and not considered by institutions – until very recently, or even until today.”
Political context
The show is an archive of an immensely rich part of Paris’s history, according to the British photographer Johny Pitts, who worked for more than a decade documenting “black Europe” in his book Afropeans.
“It reminds us that, as well as the art, it is important to show the conditions of production of the art, the politics behind the art, the intellectual movements that have helped to spearhead many black artistic traditions,” he told RFI. “And I’m really glad because sometimes I feel like that gets lost.”
Beyond appreciating the visuals, for him the exhibition helps to highlight the political context in which the art was made.
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Post-colonial artists reimagine the future in new Pompidou exhibition in Metz
“I think it’s a very important intervention,” he added. “I loved seeing the collection of Présence Africaine, the books all displayed, and also the work of photographers like Haitian Henri Roy, who’s one of my favourite photographers and has been going for a long time: here, finally, he gets his credit. There’s a lot of work in here that I have seen for the first time, and then artists whose work I actually didn’t know. It’s just so powerful.”
Pitt’s photographs were recently exhibited in the French capital by Little Africa, an art space in Paris’s Goutte d’or neighbourhood founded by a group of African cultural players.
Curated with Little Africa, numerous art, cultural and educational shows have been scheduled in venues across Paris and the Île-de-France region as parallel events reflecting “black Paris” to run intended with the Pompidou Centre’s exhibition.
‘Paris Noir’ is at the Pompidou Centre in Paris until 30 June, 2025.
Read or Listen to this story on the RFI website.
AllAfrica publishes around 400 reports a day from more than 110 news organizations and over 500 other institutions and individuals, representing a diversity of positions on every topic. We publish news and views ranging from vigorous opponents of governments to government publications and spokespersons. Publishers named above each report are responsible for their own content, which AllAfrica does not have the legal right to edit or correct.
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AllAfrica is a voice of, by and about Africa – aggregating, producing and distributing 400 news and information items daily from over 110 African news organizations and our own reporters to an African and global public. We operate from Cape Town, Dakar, Abuja, Johannesburg, Nairobi and Washington DC.
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UPND Urges Zambians to Ignore Opposition Claims

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By Mark Ziligone

The ruling United Party for National Development -UPND- has urged Zambians to disregard some opposition political parties who continue to politicize the Constitution amendment process.

UPND Media Director, MARK SIMUUWE says there is nothing secretive about the reforms and that the process will be transparent

Mr. SIMUUWE has expressed disappointment that some opposition parties are dragging President HAKAINDE HICHILEMA into the issue, despite the fact that he has no direct control over it.

During a press briefing in Lusaka today, Mr. SIMUUWE clarified that President HICHILEMA does not sit in parliament adding that accusations that he is trying to manipulate the constitution are baseless.

And opposition United National Independence Party -UNIP- has welcomed the proposed constitution reforms.

UNIP Coordinator, Reverend ALFRED BANDA said the party fully supports the process and will offer its full backing to the constitution reforms.

The post UPND Urges Zambians to Ignore Opposition Claims appeared first on ZNBC-Just for you.

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Africa: The Political Declaration's Vision Must Be Made Real – Change is There Now to be Grasped

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Closing remarks by Ms. Sima Bahous, UN Under-Secretary-General and UN Women Executive Director, at the 69th session of the Commission on the Status of Women, 21 March 2025, UN headquarters.
[As delivered.]
This Commission on the Status of Women has shown that, whatever the headwinds, the United Nations is still the place where consensus can be found on gender equality. As this 69th Commission on the Status of Women closes, we share a deep recognition of the challenges and opportunities of gender equality. They have been articulated frequently, eloquently, and effectively these last two weeks—in an exceptional year.
We have seen stakeholders—be they from within or outside of government, national, global, or grassroots—we have seen them come together in a shared agenda and determination to do more together than could be done alone.
I thank His Excellency Ambassador Abdulaziz Alwasil of Saudi Arabia as Chair of the Commission who, together with the very able Vice Chairs and co-facilitators of the Political Declaration, her Excellency, Ms. Maritza Chan Valverde of Costa Rica and Ms. Dúnia Eloisa Pires do Canto of Cabo Verde, so ably shepherded the Political Declaration to a consensual outcome.
I also thank the Vice Chairs, Ms. Robin Maria de Vogel of the Netherlands and Ms. Nataliia Mudrenko of Ukraine, for advancing the multi-year programme of work and serving as the rapporteur for the session, respectively.
I believe that I speak for all of us when I say that this Bureau, under Saudi Arabia’s leadership, managed immense challenges and, even in the face of strong headwinds, was able to stay the course for ALL women and girls.
I thank Saudi Arabia also for sharing your story of progress and women’s empowerment through your different side events, and through the special musical opening and various exhibitions on the margins of the Commission.
Allow me to congratulate and celebrate all the women who have assumed leadership positions this very week. In Namibia, the first woman President, who is inaugurated today. In Tunisia, the new woman Prime Minister, appointed yesterday. And at the International Olympics Committee, the first woman and the first African President.
This year we mark 30 years since the Beijing Declaration, 25 since Security Council resolution 1325, five years to go until 2030, and 15 years since the establishment of UN Women. We salute all women and girls around in the world, in different contexts and in different situations.
These anniversaries that we are talking about are more than moments in time: they are rallying cries, essential calls to action, powerful reminders that, as the Beijing Declaration affirms, women’s rights are human rights.
In a world under strain, the multilateral system is more essential than ever. And among the greatest rewards it offers these United Nations is its unique contribution to delivering on the promise of gender equality for ALL women and girls.
We share a deep sadness at the ceasefire in Gaza being shattered, at more civilians killed, more women and girls displaced and denied the necessities that dignity demands. We salute all women living in conflict for their courage and their resilience. And, also, we call for peace for all women and girls. We call for peace worldwide, and we stand in solidarity alongside all those women and girls enduring suffering in conflict zones around the world.
This CSW69 has sent a clear message in the Political Declaration. That message lies not only in its content but in the consensus and the commitment to progress it represents. We can all be proud to have been a part of this Political Declaration.
The Political Declaration “affirms that gender equality and the empowerment of all women and girls are essential for sustainable development and fulfilling our pledge to leave no one behind”. It recognizes that, “30 years after the Fourth World Conference on Women, no country has fully achieved gender equality and the empowerment of women and girls [and] that major gaps and obstacles remain”.
The Political Declaration is both commitment and challenge .  Let no one underestimate what was achieved here at this CSW and the impact it will have on the lives of women and girls.
The Political Declaration’s steps forward are substantial, demanding that we:
The Declaration also reaffirms our shared commitment to CSW revitalization, to the Pact for the Future, and the Secretary-General’s System-wide Gender Equality Acceleration Plan.
And it calls for the nomination of women for future UN leadership positions, for Secretary-General, and for President of the General Assembly.
This is indeed an impressive list. We have seen that these crucial commitments enjoy wide support at many levels.
This year’s CSW drew over 13,000 participants in total: 186 Member States were represented, among them one Vice President, three Deputy Prime Ministers, and 97 Ministers. We also had the participation of over 5,845 NGO representatives—a new record for CSW—and we had a total of 283 side events, many spearheaded by Member States.
Across CSW, we heard from young feminists, girl leaders, and civil society, including in a powerful Civil Society Townhall with the Secretary-General.
This year, we once again raised the bar for the energy in the corridors. Anyone working for the cause of gender equality who seeks to be inspired or energized could have done no better than to spend the last two weeks here with you all.
Allow me to extend a special thank you to the youth delegates and to civil society who were so indispensable throughout this CSW. I know for many the journey here was not easy. I salute you, your courage, and your unstoppable determination.
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Our job now, as it is every year, is to take our commitments, this energy, from these halls to the places where women and girls live their lives. Because our efforts are judged not here, but there.
To this end, and in light of the 30th anniversary of Beijing, I offer you two proposals:
First ,  we must continue to find consensus, even in difficult times. Not consensus at any price, nor consensus for its own sake, but consensus because we have shown that consensus on progress is not just possible, it is there to be achieved. And this year, you have achieved it.
Second ,  we must continue to examine every decision, every investment, every policy and more, to align it with the Beijing Declaration and Platform for Action and this Political Declaration. The Beijing+30 Action Agenda also serves as a practical guide to potential priorities in 2025 and beyond.
I will close by echoing, as I did at the opening of this august body, the words of the Beijing Declaration: “[to advance] the goals of equality, development and peace for all women everywhere in the interest of all humanity”.
We have everything to gain from gender equality. The Declaration’s vision must be made real. Change is long-overdue, we have been promised it too long, and it is there now to be grasped.
It has been an honour and a pleasure to work with all of you at this CSW69, and I look forward to working with you in the years ahead.
I thank you very much.
Read the original article on UN Women.
AllAfrica publishes around 400 reports a day from more than 110 news organizations and over 500 other institutions and individuals, representing a diversity of positions on every topic. We publish news and views ranging from vigorous opponents of governments to government publications and spokespersons. Publishers named above each report are responsible for their own content, which AllAfrica does not have the legal right to edit or correct.
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